Clomid in the treatment of Infertility

A brief description of the drug Clomid, the area of its application

Description of the drug Clomid

Due to its properties and pharmacological action, Clomid is a unique drug. Its main field of application is the treatment of such a disease as infertility in women. In addition, it is also used for anemia, ovarian disease (polycystic), amenorrhea and other diseases associated with dysfunction of the reproductive system.

Clomiphene citrate is an anti-estrogen drug prescribed to women for the treatment of anovulatory infertility (inability to ovulate). In clinical medicine, the drug belongs to the group of nonsteroidal ovulation stimulants. Clomid interacts with estrogen receptors, often antagonistically, in various tissues of the body, including the hypothalamus, pituitary, ovaries, endometrium, vagina and cervix.

Clomid counteracts the negative feedback of estrogen on the hypothalamic-pituitary-ovarian axis, increasing the release of gonadotropin (LH and FSH). This surge in gonadotropin levels can lead to the release of an egg (follicular rupture), which ideally results in conception.

Clomiphene citrate is an anti-estrogen drug

Chemically, clomiphene citrate is a synthetic estrogen that has both agonistic and antagonistic properties, and in this regard, clomiphene is very similar in structure and action to Nolvadex. It is believed that the estrogenic and anti-estrogenic properties of clomiphene play an important role in its ability to support conception in women.

Side effects of Clomid (visual symptoms)

Some patients using clomiphene citrate have reported side effects such as blurred vision or other visual impairment, such as blemishes or flashes. These symptoms are most often observed when taking higher doses or longer use of the drug and often they disappear after a few days or weeks of using Clomid.

However, after discontinuation of clomiphene citrate, cases of prolonged visual impairment were also reported, which in some cases were irreversible. Users taking clomiphene citrate should be aware that with such symptoms, driving or operating heavy machinery is very risky.

Preparation for the course of treatment with Clomid and method of its use

Before the start of the Clomid course, the patient must be examined, during which her body will be examined for the presence of gynecological or endocrine disorders.

Course of treatment with Clomid

The drug Clomid is available in pill form. The course begins with the end of the menstrual cycle. On the fifth day after the end of menstruation, the first course begins: 50 mg per day. The course lasts 5 days. In the event that the effect is reached, the pill is discontinued. If the desired effect was not achieved, after 30 days, the course is repeated, increasing the daily dosage to 100 mg.

Repetition of the course is considered inappropriate if the effect has not been achieved.

Instructions for use of the drug Clomid (Clomiphene)

Clomid, according to the instructions prescribed for the treatment of:

  • Disgonadotropic form of amenorrhea;
  • Infertility, including anovulatory infertility and dysfunctional metrorrhagia;
  • Galactorea, developing on the background of a pituitary tumor;
  • Secondary and post-contraceptive amenorrhea;
  • Chiari-Frommel syndrome;
  • Polycystic ovary syndrome;
  • Oligospermia;
  • Androgen deficiency.

Clomid is also used in the diagnosis of disorders of the gonadotropic function of the pituitary gland.

To stimulate ovulation, Clomid, according to the instructions, is prescribed 50 mg once a day. The recommended time for taking the medicine is before bedtime, the duration is 5 days. It is necessary to begin use of drug from the fifth day of a menstrual cycle, at its absence – at any time.

Clomid course to stimulate ovulation

If ovulation has not occurred within 30 days, an increase in the dosage of Clomid three times or an increase in the duration of therapy to 10 days is possible.

The maximum course dosage of Clomid is 1 g (1000 mg).

The onset of ovulation is determined based on various factors:

  • Growth of serum progesterone during the likely middle phase of lutealization;
  • The average cyclic increase of LH production;
  • The presence of a two-phase basal temperature;
  • Menstrual bleeding in women with amenorrhea.

If ovulation was, but pregnancy did not come, usually the method is repeated in the same dosage.

In cases where ovulation is likely to take place, but after there was no menstrual bleeding, before taking the next treatment course, pregnancy should be excluded.

When applying Clomid, it is necessary to take into account that the drug increases the likelihood of multiple pregnancy.

According to the instructions, Clomid is effective at high levels of endogenous estrogens, and less effective – at low levels, it has almost no therapeutic effect against the background of a low concentration of pituitary gonadotropic hormones.

Treatment with Clomid should be carried out under the supervision of a gynecologist, and it is also necessary to monitor the function of the ovaries and the phenomenon of “pupil”.

Infertility treatment with Clomid

Men for 3-4 months Clomid is prescribed 1-2 times a day at 50 mg with systematic control of the spermatogram.

Clomid was developed for:

  • Stimulation of ovulation in women with infertility due to secondary ovarian hypofunction, mainly due to the hypothalamic-pituitary disorders.
  • Stimulate ovulation in women suffering from anovulatory cycle;
  • Elimination of amenorrhea caused by insufficient gonadotropin production;
  • Treatment of androgen deficiency in men and oligospermia;
  • Diagnosis of the causes of impaired gonadotropic brain function (pituitary).

In addition, Clomid is actively used in bodybuilding and sports to normalize the body’s work on the production of endogenous hormones after a course of steroids. Such application of Clomid is not provided for by drug manufacturers, but is the result of the personal experience of men involved in body building. Therefore, few medical professionals will be able to advise and prescribe Clomid (Clomiphene) for this purpose.

Dosing of Clomid tablets depends on the purpose of the drug.

Clomid regimen for infertility problems

Clomid regimen for infertility
  • In order to stimulate ovulation, the instructions for use of Clomid recommends that women take 50 mg of the drug daily (at bedtime). Therapy begins on the 5th day of the monthly cycle. The course is 5 days. In the absence of the effect, a repeated dose of the drug is administered (up to 3-6 courses), increasing the dosage of Clomid to 150 mg or extending the duration of therapy, bringing the course to 10 days. It is important not to exceed the total dose for the entire cycle of administration – 1 g of the active substance.
  • Infertility in men. For men experiencing problems with spermatogenesis, it is recommended to take Clomid 1-2 times a day, 50 mg. During the course, a man must check spermogram.

Recovery scheme with Clomid after a course of steroids

The recovery scheme using Clomid depends on the duration of the course and the number of stimulants taken. The stronger was the dosage of steroids and the longer the cycle lasted, the longer it would take to restore the body’s functions to normal.

After the ultralight course: 15 days X 50 mg, then the next 15 days X 25 mg;

After the easy course: 15 days X 50 mg, 15 days X 25 mg, 15 times (1 time in 2 days) 25 mg each;

After a moderate intake: 30 days X 50 mg, 15 days X 25 mg;

After intensive reception: 15 days X 100 mg, 15 days X 50 mg, 15 days X 25 mg;

After overdose: 3 days X 150 mg, 12 days X 100 mg, 15 days X 50 mg, 15 days X 25 mg.

To restore the production of your own testosterone, other anti-estrogens are also used. What works best depends on many factors.

Several pairs of drugs are compared:

  • Clomid or Tamoxifen? Competing drugs are similar in structure, but the latter is stronger. Therefore, to restore testosterone it requires less. However, it is believed that Clomid is the best choice for PCT after taking progestins.
  • Proviron or Clomid? Both medications have an anti-estrogenic effect, but each of them acts in its own way. The difference is as follows: Clomid stimulates the body’s tissues to release hormones, which increases endogenous testosterone levels, and Proviron suppresses the enzymes responsible for the transformation of steroid hormones into estrogens. Due to this process slows down, which leads to the accumulation of testosterone in the plasma. But the effect is temporary, so after some time the level of the male hormone will drop again.

While taking anabolic steroids, the level of androgens is extremely high, and therefore the body does not need to synthesize its own substances. The hypothalamus stops giving commands to the pituitary gland to make hormones. Until the concentration of substances received from outside will be maximum in the body, Clomid will not be able to stimulate the work of the body. The drug can be taken during the steroid cycle only as an anti-estrogen agent.

The drug Clomid is prohibited for pregnant and lactating mothers. Women of reproductive age in the event of the appointment of Clomid should ensure that no pregnancy.

Clomiphene citrate is approved by the FDA for the treatment of ovulatory dysfunction in women, preventing pregnancy. The recommended dose of Clomid is 50 mg per day for 5 days. If ovulation has not occurred, in the following cycles, doses of 100 mg per day can be used for 5 days. Many doctors recommend that therapy be limited to six courses.

When men are using Clomid (not for their intended purpose) to mitigate the estrogenic side effects of anabolic / androgenic steroids, the usual daily dose of Clomid is 50-100 mg (1-2 tablets). We note, however, that for these purposes Tamoxifen is generally considered the preferred drug.

Contraindications for the drug Clomid

Contraindications to the use of Clomid are:

  • Hepatic and renal failure;
  • Pregnancy;
  • Hypersensitivity to clomiphene or auxiliary components of the drug;
  • Ovarian cyst;
  • Metrorrhagia of unclear etiology;
  • Neoplasms of the genitals;
  • Tumor or hypofunction of the pituitary gland;
  • Ovarian failure due to hyperprolactinemia;
  • Endometriosis.

In the treatment of infertility in women, Clomid is taken only on prescription. It is used as a stimulator of ovulation and is prescribed for infertility, which arose against the background of hypofunction of the second stage ovary.

Clomid is not assigned to women in the presence of at least one of the following factors:

  • Individual hypersensitivity to the ingredients;
  • Insufficient liver and kidney function;
  • Intermenstrual bleeding of unknown origin;
  • Benign ovarian formation (cyst);
  • Tumors of the genitals;
  • New growth or increased activity of the pituitary gland;
  • Excessive proliferation of endometrial tissue (endometriosis);
  • Violation of the functioning of the ovaries due to increased blood levels of the hormone prolactin;
  • Pregnancy and breastfeeding.

Video: Infertility Treatment: Clomid (Gynecology)