- 1 Clomid Pharmachologic Effect
- 2 Instructions for use Clomid to get Pregnancy: Method and Dosage
- 3 Clomid during Pregnancy and Breastfeeding
- 4 Do I need to take Clomid on a Course of Steroids?
- 5 What dose for the Induction of Ovulation, suppression of lactation or with oligospermia?
- 6 Elimination of Amenorrhea
- 7 Using Clomid at the Old Age
- 8 Disturbances of gonadotrophic pituitary gland function
- 9 Special Instructions for Taking Clomid
- 10 Drug Interactions
- 11 Clomid Contraindications
- 12 Side effects
- 13 Clomid Overdose
- 14 Clomid Analogs
Clomid is a hormonal drug that, under certain indications, is prescribed to women, and is also in demand among men who want to build up the muscles of the body. The active substance of the drug is clomiphene citrate. Each tablet contains 50 mg of the active ingredient.
For the Clomid preparation, the instruction is detailed and accessible in a language, so it must be carefully studied before use. Since 2004, Clomid was banned in Russia due to the cancellation of registration. Since then, it’s impossible to buy it at the pharmacy.
Even under the prescription of the medicine is not available and can not be ordered. However, pharmacological enterprises produce different analogues based on identical active substances.
Clomid Pharmachologic Effect
The drug Clomid has a hormonal effect on the patient’s body. Being a synthetic estrogen, it works like an anti-estrogen. The fact is that the active component of the tablets does not bind to the estradiol receptors. As a result, it does not cause such problems, which provoke drugs that affect the level of natural estrogens.
Pharmacological action Clomid is the starting point for the formation of a list of indications for use:
- Infertility caused by anovulatory cycles (to stimulate the maturation of follicles);
- spontaneous uterine bleeding;
- absence of menstruation;
- the appearance of milk in the mammary glands, not associated with the process of breastfeeding;
- androgenic failure;
- ovarian enlargement due to the formation of multiple cysts (PCOS);
- oligospermia in men;
- study of the causes of gonadotropic pituitary gland disorders.
Used in minimal doses, the drug Clomid, stimulates ovulation due to increased production of LH, FSH and prolactin. When taking large amounts of medicine has an antiestrogenic effect, inhibiting the secretory activity of gonadotropins.
After consumption it is quickly absorbed into the bloodstream, has a prolonged effect and is excreted for at least a week.
Instructions for use Clomid to get Pregnancy: Method and Dosage
Clomid instructions for use are recommended for oral use. The standard dosage of the drug is in one tablet and is 50 mg. In accordance with the indications and nature of the pathology, the volumes and the frequency of use of the hormonal agent can vary.
They are set by the doctor individually after a preliminary examination and a full study of the anamnesis. If the medicine is used once a day, then it should be drunk before bedtime without first grinding or chewing.
Clomid during Pregnancy and Breastfeeding
Pregnancy and conception are one of the goals pursued by Clomid. However, with a confirmed pregnancy, it can not be taken.
Before you begin treatment, you need to make sure that there is none.
During lactation, the antiestrogen is not used. The medicine is able to penetrate into breast milk, as a result of which it will reach the child.
Do I need to take Clomid on a Course of Steroids?
Use it with steroids does not make sense, since the latter significantly increase the level of androgens in the body. Because of this, the hypothalamic-pituitary system ceases to produce its own testosterone. Using at this time Clomid, a person will not achieve any result.
The drug can not support the testosterone level, and its reception will be a waste of money. It should be noted that the cost of the drug is approaching $15 per package.
Reception of Clomid after a course of steroids will bring a greater effect. In this case, it is necessary to take into account the half-life of the substances used. It is important and not to miss the time, because the later use of the drug will cause the muscles to begin to deteriorate.
The standard dosage of the drug for athletes begins with 150 mg and gradually decreases to one tablet per day.
What dose for the Induction of Ovulation, suppression of lactation or with oligospermia?
For women, the drug is prescribed to stimulate ovulation. Its undoubted advantage is that it does not cause adverse consequences. For the induction of the ovulatory cycle, Clomid is used one tablet from the first day of bleeding. The period of its application is 5 days.
In the absence of ovarian response within 30 days, the dose of the drug increases threefold and reaches 150 mg, or the period of use is prolonged to 10 days. The total amount of medicine taken during the cycle should not exceed 1 gram. The effectiveness of the drug is assessed by measuring the basal temperature, monitoring the level of LH by tests and laboratory tests.
Despite the fact that breastfeeding is a contraindication to treatment, the drug is widely used to lower the level of prolactin after childbirth. If a woman for any reason is forced to collapse breastfeeding, then she needs Clomid for 5 days for 100 mg.
The drug helps men with oligospermia – reducing the level of sperm in the total volume of ejaculate. The regimen assumes the use of Clomid 25-100 mg per day. The duration of treatment is determined by the rate of improvement in spermogram indices.
Elimination of Amenorrhea
Amenorrhea is the absence of menstrual bleeding for several months. If the cycle is broken, the Clomid is taken any day and lasts 5-10 days, depending on the obstetric anamnesis.
It is advisable to find out the causes of menstruation irregularities. If the therapeutic effect is absent during the three courses of admission, an alternative method for the treatment of amenorrhea is selected.
Using Clomid at the Old Age
In the elderly, the use of Clomid is inexpedient. The drug can be administered to achieve an anti-estrogenic effect in women during menopause, in order to prevent endometrial hypertrophy.
Indications for this will be breakthrough uterine bleeding and an abnormal increase in the level of the glandular layer of the uterus. However, specialists prefer to use Clomid analogs for this purpose, for example, Tamoxifen.
Disturbances of gonadotrophic pituitary gland function
The drug is used as an aid to diagnose the causes of disorders of the gonadotropic function of the pituitary gland.
The minimum dose of the drug for women is 50 mg per day. The duration of the reception is determined by the diagnostic results.
Special Instructions for Taking Clomid
Instructions for use on the drug Clomid reports that its use increases the likelihood of multiple pregnancies.
As a result of simulation, ovulation can occur not in one ovary, but immediately in two. The drug shows good efficacy at a high level of its own estrogens, medium at normal or low and practically zero in the absence of synthesis of gonadotropic hormones.
The use of Clomid implies observance of caution in performing responsible work or driving vehicles.
The drug is well compatible with substances that cause the synthesis of gonadotropic hormones. When ovulation induction is often combined with the hormones of the second phase.
It is not recommended to drink alcohol (low-strength alcohol including) together in Clomid, as its effectiveness decreases. When taking large doses of alcohol, intoxication occurs.
The list of contraindications to the use of Clomid is small. Before the beginning of therapy, the patient should be convinced of the absence of such:
- hypersensitivity to the active substance;
- insufficiency of the liver and kidneys;
- ovarian tumors;
- bleeding from the genital tract of unclear etiology;
- a pituitary tumor;
- pituitary insufficiency;
- increased level of prolactin in combination with insufficiency of the gonads;
- the possibility of blood clots;
Most patients who used the medicine as prescribed by the doctor, tolerate it well. Side effects can develop against a background of an overdose, a combination with alcohol or from the use of the drug in the presence of contraindications.
The medicine affects the nervous system than provokes inhibition of reactions, headaches, drowsiness. The likelihood of dyspeptic disorders will be lower if taking medication before bed.
In the daytime, it can cause nausea and vomiting. Allergic reactions develop with intolerance to the active substance and require an urgent discontinuation of the drug. Rarely can there be flushes to the face, visual impairment, alopecia, tenderness in the mammary glands.
When taking large doses of a medicine there is a feeling of heat, hot flashes, red face, increased sweating. The patient may have impaired vision. These symptoms do not have specific treatment and go away after the drug is withdrawn.
It is necessary to seek medical help for the development of those.
Due to the abolition of Clomid registration in Russia, patients are trying to find analogues. If the medicine is prescribed by a doctor, then difficulties with the selection of an alternative remedy do not arise.
The gynecologist tells the woman about what means to buy instead of Clomid, how much to take it and how much. It is more difficult for those patients who are engaged in self-medication.
For them, the list of alternative means is small:
- Tamoxifen: a stronger drug, requires the use of smaller doses;
- Proviron: prevents the transformation of steroid hormones into estrogens;
- Clostilbegyt: more often used in women for induction of ovulation;
- Serofen: a medicament similar in the active substance.
Clomid’s reviews and their analogues are different. An important role is played by the use of drugs. Women are happy with the treatment, as a result of which they were able to become pregnant. However, like any stimulant, Clomid can cause a complication – ovarian hyperstimulation syndrome.